Invasive Group A Strep Infections Surge in U.S.

A recent CDC study published in JAMA has revealed a significant rise in invasive group A Streptococcus (GAS) infections in the U.S., with cases more than doubling from 2013 to 2022. The incidence increased from 3.6 to 8.2 cases per 100,000 people, affecting vulnerable populations such as the elderly, those in long-term care, the homeless, and injection drug users. While the rate was highest among adults aged 65 and older, the most significant increase occurred in adults aged 18 to 64, partially due to increased antibiotic resistance and higher rates of underlying health conditions like obesity and diabetes. The CDC emphasizes the need for accelerated prevention and control measures, especially with the growing diversity of emm types contributing to resistance. Notably, the situation is alarming in North America compared to other high-income countries, highlighting social disparities where the disease thrives. Nearly 2,000 deaths were attributed to these infections, underscoring the critical public health challenge as invasive strep infections transition from mild illnesses to life-threatening conditions.